|
Breast Carcinoma
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of breast
|
0.560 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Neoplasm of uncertain or unknown behavior of breast
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast adenocarcinoma
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Other members of the fibroblast growth factor family have been either not expressed in the human breast (FGF3, FGF4) or have been found at much reduced levels in breast cancer (FGF1, FGF2) and this is the first member of the family to potentially influence the progression of breast cancer through stimulation of cell division.
|
9184170 |
1997 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, overexpressing OCT3 stimulated endogenous FGF-4 expression in MCF7 breast cancer cell line.
|
12841847 |
2003 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mechanisms, including ras activation, fibroblast growth factor 4 expression, and human DNA methyltransferase activation causing ER promoter methylation, which are respectively known to induce estrogen-independent growth, induce spontaneous metastasis, and decrease ER levels in breast carcinoma experimentally, were not mechanisms operating in the hybrids.
|
8758927 |
1996 |
|
Malignant neoplasm of breast
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Other members of the fibroblast growth factor family have been either not expressed in the human breast (FGF3, FGF4) or have been found at much reduced levels in breast cancer (FGF1, FGF2) and this is the first member of the family to potentially influence the progression of breast cancer through stimulation of cell division.
|
9184170 |
1997 |
|
Malignant neoplasm of breast
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, overexpressing OCT3 stimulated endogenous FGF-4 expression in MCF7 breast cancer cell line.
|
12841847 |
2003 |
|
Mammary Neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
While overexpression of FGF-4 in the MCF-7 breast carcinoma cell line confers the ability to form spontaneously metastasizing tumors in ovariectomized nude mice without estrogen supplementation and in mice that receive tamoxifen pellets, the response of a cell to individual FGFs can be controlled at multiple levels, and the significance of FGF-1 expression in human breast tumors is uncertain.
|
9366526 |
1997 |
|
Mammary Neoplasms
|
0.330 |
AlteredExpression
|
group |
LHGDN |
The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.
|
12841847 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To get more insight into the role of 11q13 amplification in bladder tumour development, we have studied the level of amplification and expression of 4 (protoonco)genes lying within the amplicon; cyclin D1, FGF3, FGF4 and EMS1 DNA amplification was found in 5/46 tumours.
|
8622895 |
1996 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, known genes within the amplified region, such as the FGF-related oncogenes INT-2 and HST-1, are very rarely expressed in these tumors.
|
2011398 |
1991 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant association between tumor stage and hst-1 expression in the nonseminoma group was found (P = 0.0002, chi 2 test).
|
1706218 |
1991 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This makes uncertain its involvement in tumour aetiology, although several in-vitro studies link Fgf4 overexpression to malignant transformation and metastatization of culture cells.
|
11146552 |
2000 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
|
25329002 |
2014 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
We also demonstrated that E7 is involved in cell self-renewal, suggesting that the HPV16 E7 oncoprotein upregulates Oct3/4, Sox2, Nanog and Fgf4 expression to maintain the self-renewal capacity of cancer stem cells.
|
27693927 |
2016 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
To investigate whether growth, invasion and metastasis of endometrial cancer cells is associated with neovascularization, the expressions of fibroblast growth factor-1 (acidic FGF), -2 (basic FGF) and -4 (hst-1) mRNAs and FGF-2 in endometrial cancers and normal endometria as controls were determined by reverse transcription-polymerase chain reaction-Southern blot and ELISA, respectively, and the relationships between their expressions and histological grades, grades of myometrial invasion or clinical stages of endometrial cancers were analyzed.
|
8685603 |
1996 |
|
Carcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Amplification of the hst-1 gene in human esophageal carcinomas.
|
3136110 |
1988 |
|
Carcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
HST-1 and INT-2 genes which is a member of fibroblast growth factor gene family, are amplified in approximately 50% of primary tumors and all the metastatic tumors of esophageal carcinomas.
|
2098274 |
1990 |
|
Carcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Prognostic significance of hst-1 gene amplification in primary esophageal carcinomas and its relationship to other prognostic factors.
|
8010723 |
1994 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We also demonstrated that E7 is involved in cell self-renewal, suggesting that the HPV16 E7 oncoprotein upregulates Oct3/4, Sox2, Nanog and Fgf4 expression to maintain the self-renewal capacity of cancer stem cells.
|
27693927 |
2016 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
|
25329002 |
2014 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma.
|
1997190 |
1991 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Inhibition by 5-fluorouracil of ERCC1 and gamma-glutamylcysteine synthetase messenger RNA expression in a cisplatin-resistant HST-1 human squamous carcinoma cell line.
|
9268987 |
1997 |